Microchimerism in Graves' Disease

Microchimerism in Graves' Disease

Microchimerism is the presence of cells from one individual in another genetically distinct individual. Pregnancy is the main cause of natural microchimerism through transplacental bidirectional cell trafficking between mother and fetus. The consequences of pregnancy-related microchimerism are under active investigation. However, many authors have suggested a close relationship linking fetal mi...

Anticardiolipin Antibodies and Immunoglobulin M and A in Graves’ Disease

Background: Graves’ disease is an autoimmune disease, characterized by the presence of antibodies directed to TSH receptor or nearby regions as well as antibodies to double strands DNA (dsDNA) anticardiolipin and nuclear antibodies. This study evaluated anticardiolipin and rheumatoid factor, such as IgA and IgM antibodies in patients with Graves’ disease. Patients and methods: Anticardiolipin a...

[Fetal microchimerism and autoimmune disease].

Microchimerism is defined by the presence of circulating cells, bi-directionally transferred from one genetically distinct individual to another. The acquisition and persistence of fetal cell microchimerism, small numbers of genetically disparate cells from the fetus in the mother, is now a well-recognized consequence of normal pregnancy. Some of the autoimmune diseases that show a predilection...

Intrathyroidal microchimerism in Graves' disease or Hashimoto's thyroiditis: regulation of tolerance or alloimmunity by fetal-maternal immune interactions?

Recent evidence suggests that uterine life sets the scene for many chronic diseases of adulthood, for which pregnancy has provided subtle but long lasting effects. Maternal diabetes mellitus (but not paternal) during pregnancy, for example, is a strong risk factor for insulin resistance and impaired glucose tolerance later in the life of the offspring (1). Such metabolic imprinting may also app...

[Graves' disease].